参考文献

[1] Li-Jian Liang，Wen-Jie Hu，Xiao-Yu Yin，et al. Adjuvant intraportal venous chemotherapy for patients with hepatocellular carcinoma and portal vein tumor thrombi following hepatectomy plus portal thrombectomy.World Journal of Surgery，2008，32：627-632.

[2] 黄金昶，李岩，胡鹏，等.中药治疗原发性肝癌门静脉癌栓40例临床观察.癌症进展，2007，5：598-601.

[3] Tameyoshi Y，Hiroaki N，Yasuharu I，et al.Successful treatment of multiple hepatocellular carcinoma with tumor thrombi in the major portal branches by intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha and hepatectomy.International Journal of Clinical Oncology，2007，12：150-155.

[4] Jang JW，SH Bae，Choi JY，et al. A combination therapy with transarterial chemo-lipiodolization and systemic chemo-infusion for large extensive hepatocellular carcinoma invading portal vein in comparison with conservative management. Cancer Chemotherapy and Pharmacology. 2007，59：9-16.

[5] Greten T F，Papendorf F，Bleck J S，et al.Survival rate in patients with hepatocellular carcinoma：a retrospective analysis of 389 patients.British Journal of Cancer，2005，92：1862-1869.

[6] Chang JY，Ka WS，Chao TY，et al. Hepatocellular carcinoma with intra-atrial tumor thrombi. A Report of three cases responsive to thalidomide treatment and literature review. Oncology，2004，67：320-325.

[7] Schöniger -Hakele M， Müller C，Kutilek M，et al. Hepatocellular carcinoma in Central Europe：Prognostic features and survival.Gut，2001，48：103-110.

[8] Shuqun C，Minshan C，Jianqiang C，et al. Chinese expert consensus on multidisciplinary diagnosis and treatment of hepatocellular carcinoma with portal vein tumor thrombus：2016 edition. Oncotarget，2016.

[9] Tai WM，Yong WP，Lim C，et al. A phase Ib study of selumetinib （AZD6244，ARRY-142886）in combination with sorafenib in advanced hepatocellular carcinoma （HCC）. Annals of Oncology ：Official Journal of the European Society for Medical Oncology，2016，27 （12）：2210.

[10] Cheng S，Yang J，Shen F，et al. Multidisciplinary management of hepatocellular carcinoma with portal vein tumor thrombus - Eastern Hepatobiliary Surgical Hospital consensus statement. Oncotarget，2016，7（26）：40816-40829.

[11] 杨振宇，杨涛，谭凯，等. 肝细胞癌伴门静脉癌栓的治疗进展. 中华肝胆外科杂志，2016，22（3）：206-210.

[12] Luo X，Zhang B，Dong S，et al. Hepatocellular carcinoma with tumor thrombus occupying the right atrium and portal vein：A case report and literature review. Medicine （Baltimore），2015，94（34）：e1049.

[13] Barosa R，Figueiredo P，Fonseca C. Acute anemia in a patient with hepatocellular carcinoma. HCC rupture with intraperitoneal hemorrhage. Gastroenterology，2015，149（3）：e3-4.

[14] Eom BW，Lee JH，Lee JS，et al. Survival analysis of gastric cancer patients with tumor thrombus in the portal vein. J Surg Oncol，2012，105（3）：310-315.

[15] Lu ZH，Shen F，Yan ZL，et al. Treatment of portal vein tumor thrombus of hepatocellular carcinoma with percutaneous laser ablation. J Cancer Res Clin Oncol，2009，135（6）：783-789.

[16] Igarashi H，Shinozaki S，Mukada T. A case of acinar cell carcinoma of the pancreas that formed extensive tumor thrombus of the portal vein. Clin J Gastroenterol，2009，2（2）：96-102.

[17] Rodriguez-Perálvarez M，Luong TV，Andreana L，et al. A systematic review of microvascular invasion in hepatocellular carcinoma：diagnostic and prognostic variability. Ann Surg Oncol，2013，20（1）：325-339.

[18] Guo W，Xue J，Shi J，et al. Proteomics analysis of distinct portal vein tumor thrombi in hepatocellular carcinoma patients. Journal of proteome research，2010，9（8）：4170-4175.