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参考文献
1. Doenicke A.Etomidate，a new intravenous hypnotic.Acta Anaesthesial Belg，1974，25（3）：307-315.
2. VanHamme MJ，Ghoneim MM，Ambre JJ.Pharmacokinetics of etomidate，a new intravenous anesthetic. Anesthesiology，1978，49：274-277.
3. Gooding JM，Weng JT，Smith RA，et al.Cardiovascular and pulmonary responses following etomidate induction of anesthesia in patients with demonstrated cardiac disease.Anesth Analg，1979，58：39-41.
4. Bovill JG.Intravenous anesthesia for the patient with left ventricular dysfunction.Semin Cardiothorac Vasc Anesth，2006，10：43-48.
5. Raichle M E，Gusnard D A.Appraising the brain’s energy budget.Proc Natl Acad Sci USA，2002，99（16）：10237.
6. Achim Peters.The Selfish Brain：Competition for Energy Resources. AMERICAN JOURNAL OF HΜMAN BIOLOGY，2011，23：29-34.
7.曹云飞，俞卫锋，王士雷.全麻原理及研究新进展.北京：人民军医出版社，2005：108-171.
8. Leslie Newberg Milde.James H.Milde，John D.Michenfelder. Cerebral Functional，Metabolic，and Hemodynamic Effects of Etomidate in Dogs.Anesthesiology，1985，63：371-377.
9. William E.Hoffman，Fady T.charbel，et al.Comparison of the effect of Etomidate and Desflurane on Brain Tissue Gases and PH during prolonged Middle Cerebral Artery Occlusion. Anesthesiology，1998，88：1184-1194.
10. Donald w.Davis，Anke M.Mans，et al.Regional Brain Glucose Utilization in Rats during Etomidate Anesthesia.Anesthesiology，1986，64：751-757.
11. Renou AM，Vernheit J，Macrez P，et al.Cerebral blood flow and metabolism during etomidate anesthesia in man. Br J Anaesth，1978，50：1047-1051.
12. Stuart A.Forman.Clinical and Molecular Pharmacology of Etomidate.Anesthesiology.2011，114（3）：695-707.
13. Watson JC，DrμMmond JC，Patel PM，et al.An assessment of the cerebral protective effects of etomidate in a model of incomplete forebrain ischemia in the rat. Neurosurgery，1992，30：540-544.
14. Robert Koorn，Timothy S.Brannan，Julian Martinez-Tica，et al.Effect of Etomidate on In Vim Ischemia-Induced Dopamine Release in the Corpus StriatμM of the Rat：A Study Using Cerebral Microdialysis. Anesth Analg 1994，78：73-79.
15. Lee J，Kim D，Hong H，et al.Protective effect of etomidate on kainic acid-induced neurotoxicity in rat hippocampus. Neurosci L eet，2000，286（3）：179-182.
16. Yu Q，Zhou Q，Huang H，et al.Protective effect of etomidate on spinal cord ischemia-reperfusion injury induced by aortic occlusion in rabbits.Ann Vasc Surg，2010，24（2）：225-232.
17. Guy J.Edelman，William E.Hoffman，Fady T.Charbel.Cerebral Hypoxia After Etomidate Administration and Temporary Cerebral Artery Occlusion.Anesth Analg，1997，85：821-825.
18.沈永倩，薛庆生，陈红专.依托咪酯对大鼠皮层、海马脑片缺氧复氧损伤的保护作用.中华麻醉学杂志，2006，26 （5）：261.
19. Heinke W，Schwarzbauer C.In vivo imaging of anaesthetic action in hμMans：Approaches with PET and fMRI. Br J Anaesth，2002，89：112-122.
20. B.W.Urban.Current assessment of targets and theories of anaesthesia.Br J Anaesth，2002，89：167-183.
21. Jason A.Talavera，BS，Steven K.Esser，BS，Florin Amzica，PhD，et al.Modeling the Gabaergic Action of Etomidate on the Thalamocortical System.Anesth Analg，2009，108：160-167.
22. Andrada J，Livingston P，Lee BJ，et al.Propofol and etomidate depress cortical，thalamic，and reticular formation neurons during anesthesic-induced unconsciousness. Anesth Analg，2012，114（3）：661-669.
23. Tomlin SL，Jenkins A，Lieb WR，et al.Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals. Anesthesiology，1998，88：708-717.
24. Yang J，Uchida I.Mechanisms of etomidate potentiation of GABAA receptor-gated currents in cultured postnatal hippocampal neurons.Neuroscience，1996，73：69-78.
25. Tomlin SL，Jenkins A，William WR，et al. Stereoselective effects of etomidate opticl isomer on gamm-aminobutyric acid type A receptors ans animals.Anesthesiology，1998，88 （4）：708-717.
26.曹云飞，俞卫锋，王士雷.全麻原理及研究新进展.北京：人民军医出版社，2005，324-331.
27. Ashton D，Wauquier A.Modulation of a GABA-ergic inhibitory circuit in the in vitro hippocampus by etomidate isomers.Anesth Analg.1985，64：975-980.
28.杜溢，刘斌.GABA A受体与全身麻醉药物作用研究的新进展.国外医学•生理、病理科学与临床分册，2002，22 （2）：138.
29. Sieghart W. Structure，pharmacology，and function of GABAA receptor subtypes.Adv Pharmacol，2006，54：231-263.
30. Olsen RW，Sieghart W.GABA（A）receptors：Subtypes provide diversity of function and pharmacology.Neuropharmacology，2008，141-148.
31. McKernan RM，Whiting PJ.Which GABAA-receptor subtypes really occur in the brain？.Trends in Neurosciences，1996，19：139-143.
32. Sem’yanov AV.Diffusional extrasynaptic neurotransmission via glutamate and GABA.Neurosci Behav Physiol.2005，35：253-266.
33. Sanna E，Murgia A，Casula A，et al.Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at gamma-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes.Mol Pharmacol，1997，51：484-490.
34. Hill-Venning C，Belelli D，Peters JA，et al.Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor.Br J Pharmacol，1997，120：749-756.
35. Rooma Desai，Dirk Ruesch，Stuart A.Forman.γ-Amino Butyric Acid Type A Receptor Mutations β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity.Anesthesiology.2009，111（4）：774-784.
36. Jurd R，Arras M，Lambert S.General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA （A）receptor beta3 subunit.FASEB Journal，2003，17：250-252.
37. Reynolds DS，Rosahl TW，Cirone J，et al.Sedation and anesthesia mediated by distinct GABA（A）receptor isoforms.J Neurosci，2003，23：8608-8617.
38. Herd MB，Haythornthwaite AR，Rosahl TW，et al.The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.J Physiol，2008，586：989-1004.
39. Cheng VY，Martin LJ，Elliott EM，et al.Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate. J Neurosci，2006，26：3713-3720.
40. Mihalek RM，Banerjee PK，Korpi ER，et al.Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.Proc Natl Acad Sci U S A，1999，96：12905-12910.
41. Jenkins A，Greenblatt EP，Faulkner HJ，et al.Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.J.Neurosci，2001，21：RC136.
42. Hunt DL，Castillo PE.Synaptic plasticity of NMDA receptors：mechanisms and functional implications. Curr Opin Neurobiol，2012.
43.焦志华，庄心良.全麻药对NMDA受体的影响.《国外医学》麻醉学与复苏分册，2002，23（1）：
44.孟晶，戴体俊，段世明，等.依托咪酯抗实验性惊厥作用及其机制.中国药理学通报，2006，22（1）：124.
45. Kochan LD，Churn SB，Omojokun O，et al.Status epilepticus results in an N-methyl-D-aspartate receptor-dependent inhibition of Ca 2+/calmodulin-dependent kina-seⅡactivity in the rat.Neuroscience，2000，95（3）：735-743.
46.冯鹏久，蒋宗滨，黄剑锋，等.依托咪酯与丙泊酚对电休克治疗脑癫痫波发作的影响.临床麻醉学杂志，2008，24 （4）：
47.丁海雷，段世明.依托咪酯的中枢神经系统作用及其分子学作用机制.《国外医学》麻醉学与复苏分册，1999，20 （6）：
48.李震，罗成，孙焱芜.依托咪酯对成年大鼠脊髓胶状质局部突触传递的作用. Acta Physiologica Sinica，2004，56 （3）：413-418.
49. Toshihiko Mitsuyo，MD，Joseph F. Antognini，MD，Earl Carstens，PhD. Etomidate Depresses LμMbar Dorsal Horn Neuronal Responses to Noxious Thermal Stimulation in Rat. Anesth Analg，2006，102：1169-1173.
50.郑超，汪萌芽.依托咪酯对新生大鼠离体脊髓运动神经元下行激活的影响.生理学报Acta Physiologica Sinica. 2012，64（2）：155-162.
51. Marco Pistis，Delia Belelli，John A.The interaction of general anaesthetics with recombianant GABA Aand glycine receptors expressed in Xenopus laevis oocytes：a comparative study. British Journal of Pharmacology，1997，122：1707-1719.
52. Maris Paola Mascia，Tina K.Machu，R.et al.Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics. British Journal of Pharmacology，1996，119：1331-1336.