1. King GL. The Role of Inflammatory Cytokines in Diabetes and Its Complications.J Periodontol，2008，79：1527-1534.

2. Lue LF，Andrade C，Sabbagh M，et al.Is There Inflammatory Synergy in TypeⅡDiabete Mellitus and Alzheimer’s Disease？.Int J Alzheimers Dis，2012，2012：918680.

3. Nogueira-Machado JA，Volpe CM，Veloso CA，et al.HMGB1，TLR and RAGE：a functional tripod that leads to diabetic inflammation.Expert Opin Ther Targets.2011，15（8）：1023-1035.

4. Reske-Nielsen E，Lundbæk K，Rafaelsen O J. Pathological changes in the central and peripheral nervous system of young long-term diabetics.Diabetologia，1966，1（3-4）：233-241.

5. Strachan M W J，Frier B M，Deary L J.Type 2 diabetes and cognitive impairment.Diabet Med，2003，20：1-2.

6. E Soares，S Nunes，F Reis，et al.Diabetic encephalopathy the role of oxidative stress and inflammation in type 2 diabetes. International Journal of Interferon，Cytokine and Mediator Research，2012，4：75-85.

7. Leinonen E S，Hiukka A，Hurt Camejo E，et al.Low-grade inflammation，endothelial activation and carotid intima-media thickness intype2 diabetes.J InternMed，2004，256（2）：119-127.

8. Suo-bin WANG，Jian-ping JIA.Oxymatrine attenuates diabetes-associated cognitive deficits in rats.Acta Pharmacologica Sinica，2014，35：331-338.

9. BaydasG，Nedzvetskii VS，TuzcuM，et al. Increase of glial fibrilary acidicprotein and S-100B in hippocampus and cortex of diabeticrats：effects of vitamin E. Eur J Pharmacol，2003，462（1-3）：67-71.

10. Hwang IK，Choi JH，Nam SM.Activation of microglia and induction of proinflammatory cytokines in the hippocampus of type 2 diabetic rats.Neurol Res，2014，36（9）：824-832.

11. Nogueira-Machado JA，Volpe CM，Veloso CA，et al. HMGB1，TLR and RAGE：a functional tripod that leads to diabetic inflammation.Expert Opin Ther Targets，2011，15 （8）：1023-1035.

12. Li J，Kokkola R，Tabibzadeh S，et al.Structural basis for the proinflammatory cytokine activity of high mobility group box 1.Mol Med，2003，9（1-2）：37-45.

13. Gao HM，Zhou H，Zhang F，et al.HMGBl Acts on Microglia Mad to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration. J Neurosci，2011，19；31 （3）：1081-1092.

14. Guazzi S，Strangio A，Franzi AT，et al.HMGBl，an architectural chromatin protein and extracellular signalling factor，has a spatially and temporally restricted expression pattern in mouse brain.Gene Expr Patterns，2003，3（1）：29-33.

15. Kim JB，Sig Choi J，Yu YM，et al.HMGB1，a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemicbrain. J Neurosci，2006，26（24）：6413-6421.

16. Fang P，Schachner M，Shen YQ. HMGB1 in development and diseases of the central nervous system.Mol Neurobiol，2012，45（3）：499-506.

17. Gao HM，Zhou H，Zhang F，et al.HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.J Neurosci，2011，31（3）：1081-1092.

18. Pedrazzi M，Patrone M，Passalacqua M.Selective Proinflammatory Activation of Astrocytes by High-Mobility Group Box 1 Protein Signaling.J Immunol，2007，179（12）：8525-8532.

19. Devaraj S，Dasu MR，Park SH，et al.Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes［J］. Diabetologia，2009，52（8）：1665-1668.

20. Dasu MR，Devaraj S，Park S，et al.Increased Toll-Like Receptor（TLR）Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects.Diabetes Care，2010，33 （4）：861-868.

21. Chavan SS，Huerta PT，Robbiati S，et al.HMGBl Mediates Cognitive Impairment in Sepsis Survivors.Mol Med，2012，18：930-937.

22. Mazarati A，Maroso M，Iori V，et al. High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products. Exp Neurol，2011，232（2）：143-148.

23. Schmidt AM，Yan SD，Yan SF，et al.The multiplying and receptor RAGE as a progression factor amplifying immune and inflammatory responses.J Clin Invest，2001，108（7）：949-955.

24. Fang F，Lue LF，Yan S，et al.RAGE-dependent signaling in microglia contributes to neuroinflammation，Abeta accumulation，and impaired learning/memory in a mouse model of Alzheimer’s disease.FASEB J，2010，24（4）：1043-1055.

25. Arancio O，Zhang HP，Chen X，et al. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.EMBO，2004，23（20）：4096-4105.

26. Liu J，Wang S，Feng L，et al.Hypoglycemic and Antioxidant Activities of Paeonol and Its Beneficial Effect on Diabetic Encephalopathy in Streptozotocin-Induced Diabetic Rats. J Med Food，2013，16（7）：577-586.

27. Kokkola R，Andersson A，Mullins G，et al.RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages.Scand J Immunol，2005，61（1）：1-9.

28. Park JS，Svetkauskaite D，He Q，et al.Involvement of tolllike receptors 2 and 4 in cellular activation by high mobility group box 1protein.J Biol Chem，2004，279（9）：7370-7377.

29. Islam MA，Cinar MU，Uddin MJ，et al.Expression of Tolllike receptors and downstream genes in lipopolysaccharideinduced porcine alveolar macrophages.Vet Immunol Immunopathol，2012，146（1）：62-73.

30. Rivest S. Regulation of innate immune responses in the brain.Nat Rev Immunol，2009，9（6）：429-439.

31. Chen YC，Yip PK，Huang YL，et al.Sequence variants of toll like receptor 4 and late-onset Alzheimer’s disease. PLoS One，2012，7（12）：e50771.

32. Dasu MR，Devaraj S，Park S，et al.Increased Toll-Like Receptor（TLR）Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects.Diabetes Care，2010，33 （4）：861-868.

33. Dasu MR，Devaraj S，Zhao L，et al.High Glucose Induces Toll-Like Receptor Expression in Human Monocytes.Diabetes，2008，57（11）：3090-3098.

34. Devaraj S，Dasu MR，Park SH，et al.Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes.Diabetologia，2009，52（8）：1665-1668.

35. Dasu MR，Devaraj S，Park S，et al.Increased Toll-Like Receptor（TLR）Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects.Diabetes Care，2010，33 （4）：861-868.

36. Kawamoto EM，Cutler RG，Rothman SM，et al. TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type1 diabetes. Biochem Biophys Res Commun，2014，443（2）：731-737.

37. E Okun，KJ Griffioen，JD Lathia，et al.Toll-like receptors in neurodegeneration.Brain Research Reviews，2009，59（2）：278-292.

38. Okun E，Barak B，Saada-Madar R，et al.Evidence for a developmental role for TLR4 in learning and memory. PLoS One，2012，7（10）：e47522.

39. Pascual M，Baliño P，Alfonso-Loeches S，et al. Impact of TLR4 on behavioral and cognitive dysfunction associated with alcohol-induced neuroinflammatory damage.Brain Behav Immun，2011，25 Suppl 1：S80-91.

40. Gasparini C，Feldmann M.NF-κB as a target for modulating inflammatory responses. Curr Pharm Des，2012，18（35）：5735-5745.

41. M Indira，PA Abhilash.Role of NF-Kappa B（NF-κB）in Diabetes.Forum on Immunopathological Diseases and Therapeutics，2013，4（2）：111-132.

42. Zhang H，Park Y，Wu J，et al.Role of TNF-αlpha in vascular dysfunction.Clin Sci（Lond），2009，116（3）：219-230.

43. Grilli M，Memo M. Nuclear factor-kappaB/Rel proteins：a point of convergence of signalling pathways relevant in neuronal function and dysfunction.Biochem Pharmacol.1999，57（1）：1-7.

44. B Kaltschmidt，D Widera，C Kaltschmidt.Signaling Via NF-kB in the nervous system.Biochimica et Biophysica Acta，2005，1745（3）：287-299.

45. Muller D，Nikonenko I，Jourdain P，et al.LTP，Memory and Structural Plasticity.Current Molecular Medicine，2002，2：605-611.

46. Meffert MK，Chang JM，Wiltgen BJ，et al.NF-kappa B functions in synaptic signaling and behavior. Nat Neurosci，2003，6（10）：1072-1078.

47. Osullivan N C，Croydon L，Mcgettigan P A，et al.Hippocampal region-specific regulation of NF-kappaB may contribute to learning-associated synaptic reorganisation. Brain Res Bull，2010，81（4-5）：385-390.

48. M Aragno，R Mastrocola，E Brignardello.Dehydroepiandrosterone Modulates Nuclear Factor-κB Activation in Hippocampus of Diabetic Rats. Endocrinology，2002，143（9）：3250-3258.

49. Kuhad A，Bishnoi M，Tiwari V，et al.Suppression of NF-κB signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits.Pharmacol Biochem Behav.2009，92（2）：251-259.