参考文献

[1] YAO X，PENG R，DING J D.Cell-Material interactions revealed via material techniques of surface patterning[J].Adv Mater，2013，25（37）：5257-5286.

[2] DEFOREST C A，TIRRELL D A.A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels[J].Nat Mater，2015，14（5）：523-531.

[3] ALBY M J，GADEGAARD N，OREFFO R O C.Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate[J].Nat Mater，2014，13（6）：558-569.

[4] SARI D P，BANG S，NGUYEN L，et al.Micro/Nano surface topography and 3D bioprinting of biomaterials in tissue engineering[J].J Nanosci Nanotechno，2016，16（9）：8909-8922.

[5] CUTIONGCO M F A，GOH S H，AID-LAUNAIS R，et al.Planar and tubular patterning of micro and nano-topographies on poly（vinyl alcohol）hydrogel for improved endothelial cell responses[J].Biomaterials， 2016， 84：184-195.

[6] CHEN Y F.Nanofabrication by electron beam lithography and its applications： a review[J].Microelectron Eng，2015，135：57-72.

[7] ZHANG W J，WANG G C，LIU Y，et al.The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration[J].Biomaterials，2013，34（13）：3184-3195.

[8] WADE R J，BURDICK J A.Advances in nanofibrous scaffolds for biomedical applications：from electrospinning to self-assembly[J].Nano Today，2014，9（6）：722-742.

[9] OZBOLAT I T，HOSPODIUK M.Current advances and future perspectives in extrusion-based bioprinting[J].Biomaterials，2016，76（37）：321-343.

[10] MUNOZ-BONILLA A，FERNANDEZ-GARCIA M，RODRIGUEZ-HERNANDEZ J.Towards hierarchically ordered functional porous polymeric surfaces prepared by the breath figures approach[J].Prog Polym Sci，2014，39（3）：510-554.

[11] RAHMOUNI S，LINDNER A，RECHENMACHER F，et al.Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops：a new tool for the measurementofcelltraction　forcestransmitted through alpha（v）beta（3）-or alpha（5）beta（1）-Integrins[J].Adv Mater，2013，25（41）：5869-5874.

[12] WANG X，LI SY，YAN C，et al.Fabrication of RGD micro/nanopattern and corresponding study of stem cell differentiation[J].Nano Lett，2015，15（3）：1457-1467.

[13] JEONG H E，LEE J K，KIM H N，et al.A nontransferring dry adhesive with hierarchical polymer nanohairs[J].Proc Nat Acad Sci USA，2009，106（14）：5639-5644.

[14] Kubo K，Tsukimura N，Iwasa F，et al.Cellular behavior on TiO₂nanonodular structures in a micro-to-nanoscale hierarchy model[J].Biomaterials，2009，30（29）：5319-5329.

[15] YANG K，JUNG H，LEE HR，et al.Multiscale，hierarchically patterned topography for directing human neural stem cells into functional neurons[J].Acs Nano，2014，8（8）：7809-7822.

[16] KIRN T G，PARK S H，CHUNG H J，et al.Hierarchically assembled mesenchymal stem cell spheroids using biomimicking nanofilaments and microstructured scaffolds for vascularized adipose tissue engineering[J].Adv Funct Mater，2010，20（14）：2303-2309.

[17] WALTERS N J，GENTLEMAN E.Evolving insights in cell-matrix　interactions：elucidating　how　non-soluble properties of the extracellular niche direct stem cell fate[J].Acta Biomater，2015，11：3-16.

[18] NIKKHAH M，EDALAT F，MANOUCHERI S，et al.Engineering microscale topographies to control the cell-substrate interface[J].Biomaterials，2012，33（21）：5230-5246.

[19] YE K，WANG X，CAO L P，et al.Matrix stiffness and nanoscale spatial organization of cell-adhesive ligands direct stem cell fate[J].Nano Lett，2015，15（7）：4720-4729.

[20] YANG K，JUNG K，KO E，et al.Nanotopographical manipulation of focal adhesion formation for enhanced differentiation of human neural stem cells[J].Acs Appl Mater Inter，2013，5（21）：10529-10540.

[21] KIM J H，KIM H W，CHA KJ，et al.Nanotopography promotes pancreatic differentiation of human embryonic stem cells and induced pluripotent stem cells[J].Acs Nano，2016，10（3）：3342-3355.

[22] GILCHRIST C L，RUCH D S，LITTLE D，et al.Microscale and meso-scale architectural cues cooperate and compete to direct aligned tissue formation[J].Biomaterials，2014，35（38）：10015-10024.

[23] KIRMIZIDIS G，BIRCH M A.Microfabricated grooved substrates influence cell-cell communication and osteoblast differentiation in vitro[J].Tissue Eng Part A，2009，15（6）：1427-1436.

[24] WATARI S，HAYASHI K，WOOD J A，et al.Modulation of osteogenic differentiation in hMSCs cells by submicron topographically-patterned ridges and grooves[J].Biomaterials，2012，33（1）：128-136.

[25] JAGGY M，ZHANG P，GREINER A M，et al.Hierarchical micro-nano surface topography promotes long-term maintenance of undifferentiated mouse embryonic stem cells[J].Nano Lett，2015，15（10）：7146-7154.

[26] PAN H H，XIE Y T，LI K，et al.ROCK-regulated synergistic effect of macropore/nanowire topography on cytoskeletal distribution and cell differentiation[J].RSC Adv，2015，5（123）：101834-101842.

[27] GLUKHOV A V，BALYCHEVA M，SANCHEZ-ALONSO J L，et al.Direct evidence for microdomain-specific localization and remodeling of functional L-type calcium channels in rat and human atrial myocytes[J].Circulation，2015，132（25）：2372-2384.

[28] NAKAMURA Y，HARADA H，KAMASAWA N，et al.Nanoscale distribution of presynaptic Ca²⁺channels and its impact on vesicular release during development[J].Neuron，2015，85（1）：145-158.

[29] WANG P Y，BENNETSEN D T，FOSS M，et al.Modulation of human mesenchymal stem cell behavior on ordered tantalum nanotopographies fabricated using colloidal lithography and glancing angle deposition[J].Acs Appl Mater Inter，2015，7（8）：4979-4989.

[30] SEQUEIRA S J，SOSCIA D A，OZTAN B，et al.The regulation of focal adhesion complex formation and salivary gland epithelial cell organization by nanofibrous PLGA scaffolds[J].Biomaterials，2012，33（11）：3175-3186.

[31] ZHAO C C，XIA L G，ZHAI D，et al.Designing ordered micropatterned hydroxyapatite bioceramics to promote the growth and osteogenic differentiation of bone marrow stromal cells[J].J Mater Chem B，2015，3（6）：968-976.

[32] LIU X G，LIN K L，WU C T，et al.Multilevel hierarchically ordered artificial biomineral[J].Small，2014，10（1）：152-159.

[33] LIN K L，XIA L G，GAN J B，et al.Tailoring the nanostructured surfaces of hydroxyapatite bioceramics to promote protein adsorption，osteoblast growth，and osteogenic differentiation[J].Acs Appl Mater Inter，2013，5（16）：8008-8017.

[34] WANG X H，ZHOU Y N，XIA L G，et al.Fabrication of nano-structured calcium silicate coatings with enhanced stability，bioactivity and osteogenic and angiogenic activity[J].Colloid Surface B，2015，126：358-366.

[35] LI L，WANG R，LI B，et al.Lithium doped calcium phosphate cement maintains physical mechanical properties and promotes osteoblast proliferation and differentiation[J].J Biomed Mat Res B Appl Biomater，2017，105（5）：944-952.

[36] YAMAGUCHI M，WEITZMANN M N.Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-kappa B activation[J].Mol Cell Biochem，2011，355（1-2）：179-186.

[37] SHI M，CHEN Z，FARNAGHI S，et al.Copper-doped mesoporous silica nanospheres，a promising immunomodulatory agent for inducing osteogenesis[J].Acta Biomater，2016，30：334-344.

[38] LI X，WANG X，JIANG X，et al.Boron nitride nanotubeenhanced osteogenic differentiation of mesenchymal stem cells[J].J Biomed Mat Res B Appl Biomater，2016，104（2）：323-329.

[39] PABBRUWE M B，STANDARD O C，SORRELL C C，et al.Bone formation within alumina tubes：effect of calcium，manganese，and chromium dopants[J].Biomaterials，2004，25（20）：4901-4910.

[40] MORAIS D S，COELHO J，FERRAZ M P，et al.Samarium doped glass-reinforced hydroxyapatite with enhanced osteoblastic performance and antibacterial properties for bone tissue regeneration[J].J Mater Chem B，2014，2（35）：5872-5881.

[41] YU L，QIAN S，QIAO Y，et al.Multifunctional Mn-containing titania coatings with enhanced corrosion resistance，osteogenesis and antibacterial activity[J].J Mater Chem B，2014，2（33）：5397-5408.

[42] NIELSEN F H.Micronutrients in parenteral nutrition：Boron，Silicon，and Fluoride[J].Gastroenterology，2009，137（5 suppl）：S55-S60.

[43] SRIVASTAVA S，KUMAR N，THAKUR R S，et al.Role of Vanadium （V）in the differentiation of C3H10t1/2 Cells towards osteoblast lineage：a comparative analysis with other trace elements[J].Biol Trace Elem Res，2013，152（1）：135-142.

[44] VASCONCELOS D M，SANTOS S G，LAMGHARI M，et al.The two faces of metal ions：from implants rejection to tissue repair/regeneration[J].Biomaterials，2016，84：262-275.

[45] KULANTHAIVEL S，ROY B，AGARWAL T，et al.Cobalt doped proangiogenic hydroxyapatite for bone tissue engineering application[J].Mater Sci Eng C Mater Biol Appl，2016，58：648-658.

[46] PRIYA B A，SENTHILGURU K，AGARWAL T，et al.Nickel doped nanohydroxyapatite：vascular endothelial growth factor inducing biomaterial for bone tissue engineering[J].Rsc Adv，2015，5（89）：72515-72528.

[47] SAGHIRI M A，ASATOURIAN A，ORANGI J，et al.Functional role of inorganic trace elements in angiogenesis-PartⅠ：N，Fe，Se，P，Au，and Ca[J].Crit Rev Oncol Hematol，2015，96（1）：129-142.

[48] HAGANDORA C K，TUDARES M A，ALMARZA A J.The Effect of Magnesium ion concentration on the fibrocartilage regeneration potential of goat costal chondrocytes[J].Ann Biomed Eng，2012，40（3）：688-696.

[49] LEE J H，MANDAKHBAYAR N，EL-FIQI A，et al.Intracellular co-delivery of Sr ion and phenamil drug through mesoporous bioglass nanocarriers synergizes BMP signaling and tissue mineralization[J].Acta Biomater，2017，60：93-108.

[50] QU T，JING J，JIANG Y，et al.Magnesium-containing nanostructured hybrid scaffolds for enhanced dentin regeneration[J].Tissue Eng Part A，2014，20（17-18）：2422-2433.

[51] SABBATINI M，BOCCAFOSCHI F，BOSETTI M，et al.Adhesion and differentiation of neuronal cells on Zndoped bioactive glasses[J].J Biomater Appl，2014，28（5）：708-718.