免疫学前沿进展(第4版)
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参考文献

[1]Chen H,He X,Wang Z,et al.Identification of human T cell receptor gammadelta-recognized epitopes/proteins via CDR3delta peptide-based immunobiochemical strategy.J Biol Chem.May 2 2008,283(18):12528-12537.

[2]Dai Y,Chen H,Mo C,et al.Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human gammadelta T cells to induce innate anti-tumor/virus immunity.J Biol Chem.May 11 2012;287(20):16812-16819.

[3]Mo C,Dai Y,Kang N,et al.Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase(MAPK)and c-Jun N-terminal kinase(JNK)signaling pathways.J Biol Chem.Jun 1 2012,287(23):19242-19254.

[4]Chen H,Ji X,Cui L,et al.Characterization of complementary determinant region 3delta in human MutS homologue 2-specific gammadelta T cells.Scand J Immunol.Feb 2015,81(2):121-128.

[5]Xi X,Zhang X,Wang B,et al.A novel strategy to screen Bacillus Calmette-Guerin protein antigen recognized by gammadelta TCR.PLoS One.2011,6(4):e18809.

[6]Chen H,You H,Wang L,et al.Chaperonin-containing T-complex Protein 1 Subunit zeta Serves as an Autoantigen Recognized by HumanVdelta2 gammadelta T Cells in Autoimmune Diseases.J Biol Chem.Sep 16 2016,291(38):19985-19993.

[7]Vavassori S,Kumar A,Wan GS,et al.Butyrophilin 3A1 binds phosphorylated antigens and stimulates human gammadelta T cells.Nat Immunol.Sep 2013,14(9):908-916.

[8]Sandstrom A,Peigne CM,Leger A,et al.The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vgamma9Vdelta2 T cells.Immunity.Apr 17 2014,40(4):490-500.

[9]Wang H,Morita CT.Sensor function for butyrophilin 3A1 in prenyl pyrophosphate stimulation of human vgamma2Vdelta2 T cells.J Immunol.Nov 15 2015,195(10):4583-4594.

[10]Riano F,Karunakaran MM,Starick L,et al.Vgamma9Vdelta2 TCR-activation by phosphorylated antigens requires butyrophilin 3 A1(BTN3A1)and additional genes on human chromosome 6.Eur J Immunol.Sep 2014,44(9):2571-2576.

[11]Rhodes DA,Chen HC,Price AJ,et al.Activation of human gammadelta T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin.J Immunol.Mar 1 2015,194(5):2390-2398.

[12]Sebestyen Z,Scheper W,Vyborova A,et al.RhoB mediates phosphoantigen recognition by vgamma9Vdelta2 T cell receptor.Cell Rep.May 31 2016,15(9):1973-1985.

[13]Gruenbacher G,Gander H,Rahm A,et al.Ecto-ATPase CD39 inactivates isoprenoid-derived vgamma9Vdelta2 T cell phosphoantigens.Cell Rep.Jul 12 2016,16(2):444-456.

[14]Kilcollins AM,Li J,Hsiao CH,et al.HMBPP analog prodrugs bypass energy-dependent uptake to promote efficient BTN3A1-mediated malignant cell lysis by vgamma9Vdelta2 T lymphocyte effectors.J Immunol.Jul 15 2016,197(2):419-428.

[15]Pellicci DG,Uldrich AP,Le Nours J,et al.The molecular bases of delta/alphabeta T cell-mediated antigen recognition.J Exp Med.Dec 15 2014,211(13):2599-2615.

[16]Roy S,Ly D,Castro CD,et al.Molecular analysis of lipid-reactive Vdelta1 gammadelta T cells identified by CD1c tetramers.J Immunol.Feb 15 2016,196(4):1933-1942.

[17]Schwacha MG,Rani M,Nicholson SE,et al.Dermal gammadelta T-cells can be activated by mitochondrial damage-associated molecular patterns.PLoS One.2016,11(7):e0158993.

[18]Schwacha MG,Rani M,Zhang Q,et al.Mitochondrial damage-associated molecular patterns activate gammadelta T-cells.Innate Immun.Apr 2014,20(3):261-268.

[19]Shibata K,Yamada H,Nakamura M,et al.IFN-gamma-producing and IL-17-producing gammadelta T cells differentiate at distinct developmental stages in murine fetal thymus.J Immunol.Mar 1 2014,192(5):2210-2218.

[20]Colpitts SL,Puddington L,Lefrancois L.IL-15 receptor alpha signaling constrains the development of IL-17-producing gammadelta T cells.Proc Natl Acad Sci U S A.Aug 4 2015,112(31):9692-9697.

[21]Nitta T,Muro R,Shimizu Y,et al.The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gammadeltaT cells.EMBO Rep.May 2015,16(5):638-653.

[22]Buus TB,Schmidt JD,Bonefeld CM,et al.Development of interleukin-17-producing Vgamma2+gammadelta T cells is reduced by ICOS signaling in the thymus.Oncotarget.Apr 12 2016,7(15):19341-19354.

[23]Nakamura M,Shibata K,Hatano S,et al.A genome-wide analysis identifies a notch-RBP-Jkappa-IL-7Ralpha axis that controls IL-17-producing gammadelta T cell homeostasis in mice.J Immunol.Jan 1 2015,194(1):243-251.

[24]Lu Y,Cao X,Zhang X,et al.PLZF Controls the Development of Fetal-Derived IL-17+Vgamma6+gammadelta T Cells.J Immunol.Nov 1 2015,195(9):4273-4281.

[25]Akitsu A,Ishigame H,Kakuta S,et al.IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vgamma6+gammadelta T cells.Nat Commun.2015,6:7464.

[26]Andersson A,Grahnemo L,Engdahl C,et al.IL-17-producing gammadeltaT cells are regulated by estrogen during development of experimental arthritis.Clin Immunol.Dec 2015,161(2):324-332.

[27]Maeda Y,Seki N,Kataoka H,et al.IL-17-ProducingVgamma4+gammadelta T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions.J Immunol.Aug 15 2015,195(4):1408-1416.

[28]Sheel M,Beattie L,Frame TC,et al.IL-17A-Producing gammadelta T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver.J Immunol.Dec 15 2015,195(12):5707-5717.

[29]Paget C,Chow MT,Gherardin NA,et al.CD3bright signals on gammadelta T cells identify IL-17A-producing Vgamma6Vdelta1+T cells.Immunol Cell Biol.Feb 2015,93(2):198-212.

[30]Maher CO,Dunne K,Comerford R,et al.Candida albicans stimulates IL-23 release by human dendritic cells and downstream IL-17 secretion by Vdelta1 T cells.J Immunol.Jun 15 2015,194(12):5953-5960.

[31]Ono T,Okamoto K,Nakashima T,et al.IL-17-producing gammadelta T cells enhance bone regeneration.Nat Commun.2016,7:10928.

[32]Rao R,Graffeo CS,Gulati R,et al.Interleukin 17-producing gammadeltaT cells promote hepatic regeneration in mice.Gastroenterology.Aug 2014,147(2):473-484 e472.

[33]Nakajima S,Kitoh A,Egawa G,et al.IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models.J Invest Dermatol.Aug 2014,134(8):2122-2130.

[34]Peng X,Xiao Z,Zhang J,et al.IL-17A produced by bothgammadelta T and Th17 cells promotes renal fibrosis via RANTES-mediated leukocyte infiltration after renal obstruction.J Pathol.Jan 2015,235(1):79-89.

[35]Kimura Y,Nagai N,Tsunekawa N,et al.IL-17A-producing CD30+Vdelta1 T cells drive inflammation-induced cancer progression.Cancer Sci.Sep 2016,107(9):1206-1214.

[36]Rei M,Goncalves-Sousa N,Lanca T,et al.Murine CD27-Vgamma6+gammadelta T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.Proc Natl Acad Sci U S A.Aug 26 2014,111(34):E3562-3570.

[37]Ma S,Cheng Q,Cai Y,et al.IL-17A produced bygammadelta T cells promotes tumor growth in hepatocellular carcinoma.Cancer Res.Apr 1 2014,74(7):1969-1982.

[38]Wu P,Wu D,Ni C,et al.gammadeltaT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer.Immunity.May 15 2014,40(5):785-800.

[39]Coffelt SB,Kersten K,Doornebal CW,et al.IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis.Nature.Jun 18 2015,522(7556):345-348.

[40]Tougaard P,Skov S,Pedersen AE,et al.TL1A regulates TCRgammadelta+intraepithelial lymphocytes and gut microbial composition.Eur J Immunol.Mar 2015,45(3):865-875.

[41]Frossard CP,Asigbetse KE,Burger D,et al.Gut T cell receptor-gammadelta+intraepithelial lymphocytes are activated selectively by cholera toxin to break oral tolerance in mice.Clin Exp Immunol.Apr 2015,180(1):118-130.

[42]Do J,Visperas A,Freeman ML,et al.gammadelta T cells support gut Ag-reactive colitogenic effector T-cell generation by enhancing Ag presentation by CD11b+DCs in the mesenteric LN.Eur J Immunol.Feb 2016,46(2):340-346.

[43]Meehan TF,Witherden DA,Kim CH,et al.Protection against colitis by CD100-dependent modulation of intraepithelial gammadelta T lymphocyte function.Mucosal Immunol.Jan 2014,7(1):134-142.

[44]Edelblum KL,Singh G,Odenwald MA,et al.gammadelta Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice.Gastroenterology.Jun 2015,148(7):1417-1426.

[45]Lee JS,Tato CM,Joyce-Shaikh B,et al.Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability.Immunity.Oct 20 2015,43(4):727-738.

[46]Rezende RM,da Cunha AP,Kuhn C,et al.Identification and characterization of latency-associated peptide-expressing gammadelta T cells.Nat Commun.2015,6:8726.

[47]Ramirez-Valle F,Gray EE,Cyster JG.Inflammation induces dermal Vgamma4+gammadeltaT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses.Proc Natl Acad Sci U S A.Jun 30 2015,112(26):8046-8051.

[48]Hartwig T,Pantelyushin S,Croxford AL,et al.Dermal IL-17-producing gammadelta T cells establish long-lived memory in the skin.Eur J Immunol.Nov 2015,45(11):3022-3033.

[49]Sulcova J,Maddaluno L,Meyer M,et al.Accumulation and activation of epidermal gammadelta T cells in a mouse model of chronic dermatitis is not required for the inflammatory phenotype.Eur J Immunol.Sep 2015,45(9):2517-2528.

[50]Han J,Lee E,Kim E,et al.Role of epidermalgammadelta T-cell-derived interleukin 13 in the skin-whitening effect of Ginsenoside F1.Exp Dermatol.Nov 2014,23(11):860-862.

[51]MacLeod AS,Rudolph R,Corriden R,et al.Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair.J Immunol.Jun 15 2014,192(12):5695-5702.

[52]Ujiie H,Shevach EM.gammadelta T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes.J Immunol.Feb 15 2016,196(4):1517-1528.

[53]Klemann C,Schroder A,Dreier A,et al.Interleukin 17,Produced by gammadelta T Cells,Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients.Gastroenterology.Jan 2016,150(1):229-241 e225.

[54]Hammerich L,Bangen JM,Govaere O,et al.Chemokine receptor CCR6-dependent accumulation of gammadelta T cells in injured liver restricts hepatic inflammation and fibrosis.Hepatology.Feb 2014,59(2):630-642.

[55]Wanke-Jellinek L,Keegan JW,Dolan JW,et al.Characterization of lung infection-induced TCRgammadelta T cell phenotypes by CyTOF mass cytometry.J Leukoc Biol.Mar 2016,99(3):483-493.

[56]Wehrmann F,Lavelle JC,Collins CB,et al.gammadelta T cells protect against LPS-induced lung injury.J Leukoc Biol.Feb 2016,99(2):373-386.

[57]Costa MF,de Negreiros CB,Bornstein VU,et al.Murine IL-17+Vgamma4 T lymphocytes accumulate in the lungs and play a protective role during severe sepsis.BMC Immunol.2015,16:36.

[58]Hu YM,Yeh CL,Pai MH,et al.Glutamine administration modulates lunggammadelta T lymphocyte expression in mice with polymicrobial sepsis.Shock.Feb 2014,41(2):115-122.

[59]Zhou J,Kang N,Cui L,et al.Anti-gammadelta TCR antibody-expanded gammadelta T cells:a better choice for the adoptive immunotherapy of lymphoid malignancies.Cell Mol Immunol.Jan 2012,9(1):34-44.

[60]He X,Chen H,Wu D,et al.Tandem-epitope peptide:a novel stimulator forgammadeltaT cells in tumor immunotherapy.Cancer Lett.Feb 1 2010,288(1):86-93.

[61]Wang Z,Zhang T,Hu H,et al.Targeting solid tumors via T cell receptor complementarity-determining region 3delta in an engineered antibody.Cancer Lett.Dec 18 2008,272(2):242-252.

[62]Zheng J,Guo Y,Ji X,et al.A novel antibody-like TCRgammadelta-Ig fusion protein exhibits antitumor activity against human ovarian carcinoma.Cancer Lett.Dec 1 2013,341(2):150-158.

[63]Zhao H,Xi X,Cui L,et al.CDR3delta-grafted gamma9delta2T cells mediate effective antitumor reactivity.Cell Mol Immunol.Mar 2012,9(2):147-154.

[64]He K,You H,Li Y,et al.TCRgamma4delta1-engineered alphabetaT cells exhibit effective antitumor activity.Mol Med.Jul 26 2016,22.

[65]Arkko S,Zlatev HP,Monkkonen H,et al.Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vgamma9Vdelta2 T cell cytotoxicity in PC-3 prostate cancer cells.Cancer Lett.Feb 1 2015,357(1):279-285.

[66]Parente-Pereira AC,Shmeeda H,Whilding LM,et al.Adoptive immunotherapy of epithelial ovarian cancer with Vgamma9Vdelta2 T cells,potentiated by liposomal alendronic acid.J Immunol.Dec 1 2014,193(11):5557-5566.

[67]Sugai S,Yoshikawa T,Iwama T,et al.Hepatocellular carcinoma cell sensitivity to Vgamma9Vdelta2 T lymphocyte-mediated killing is increased by zoledronate.Int J Oncol.May 2016,48(5):1794-1804.

[68]Di Carlo E,Bocca P,Emionite L,et al.Mechanisms of the antitumor activity of human Vgamma9Vdelta2 T cells in combination with zoledronic acid in a preclinical model of neuroblastoma.Mol Ther.May 2013,21(5):1034-1043.

[69]Jarry U,Chauvin C,Joalland N,et al.Stereotaxic administrations of allogeneic human Vgamma9Vdelta2 T cells efficiently control the development of human glioblastoma brain tumors.Oncoimmunology.Jun 2016,5(6):e1168554.

[70]Santolaria T,Robard M,Leger A,et al.Repeated systemic administrations of both aminobisphosphonates and human Vgamma9Vdelta2 T cells efficiently control tumor development in vivo.J Immunol.Aug 15 2013,191(4):1993-2000.

[71]Duault C,Franchini DM,Familliades J,et al.TCRVgamma9 gammadelta T Cell Response to IL-33:A CD4 T Cell-Dependent Mechanism.J Immunol.Jan 1 2016,196(1):493-502.

[72]Yoshikawa T,Takahara M,Tomiyama M,et al.Large-scale expansion of gammadelta T cells and peptide-specific cytotoxic T cells using zoledronate for adoptive immunotherapy.Int J Oncol.Nov 2014,45(5):1847-1856.

[73]de Bruin RC,Lougheed SM,van der Kruk L,et al.Highly specific and potently activating Vgamma9Vdelta2-T cell specific nanobodies for diagnostic and therapeutic applications.Clin Immunol.Aug 2016,169:128-138.

[74]Wu D,Wu P,Wu X,et al.Ex vivo expanded human circulating Vdelta1 gammadelta T cells exhibit favorable therapeutic potential for colon cancer.Oncoimmunology.Mar 2015,4(3):e992749.

[75]Almeida AR,Correia DV,Fernandes-Platzgummer A,et al.Delta One T cells for immunotherapy of chronic lymphocytic leukemia:clinical-grade expansion/differentiation and preclinical proof-of-concept.Clin Cancer Res.Jun 15 2016.

[76]Fisher JP,Yan M,Heuijerjans J,et al.Neuroblastoma killing properties of Vdelta2 and Vdelta2-negative gammadelta T cells following expansion by artificial antigen-presenting cells.Clin Cancer Res.Nov 15 2014,20(22):5720-5732.

[77]Deniger DC,Maiti SN,Mi T,et al.Activating and propagating polyclonal gamma delta T cells with broad specificity for malignancies.Clin Cancer Res.Nov 15 2014,20(22):5708-5719.

[78]Deniger DC,Switzer K,Mi T,et al.Bispecific T-cells expressing polyclonal repertoire of endogenous gammadelta T-cell receptors and introduced CD19-specific chimeric antigen receptor.Mol Ther.Mar 2013,21(3):638-647.

[79]Bhat J,Kabelitz D.gammadelta T cells and epigenetic drugs:A useful merger in cancer immunotherapy?Oncoimmunology.Jun 2015,4(6):e1006088.

[80]Gonnermann D,Oberg HH,Kellner C,et al.Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against gammadelta T cell cytotoxicity.Oncoimmunology.Mar 2015,4(3):e988460.

[81]Lamb LS,Jr.,Bowersock J,Dasgupta A,et al.Engineered drug resistant gammadelta T cells kill glioblastoma cell lines during a chemotherapy challenge:a strategy for combining chemo-and immunotherapy.PLoS One.2013,8(1):e51805.

[82]Chitadze G,Lettau M,Luecke S,et al.NKG2D-and T-cell receptor-dependent lysis of malignant glioma cell lines by human gammadelta T cells:Modulation bytemozolomide and A disintegrin and metalloproteases10 and 17 inhibitors.Oncoimmunology.Apr 2016,5(4):e1093276.

[83]Fisher JP,Flutter B,Wesemann F,et al.Effective combination treatment of GD2-expressing neuroblastoma and Ewing’s sarcoma using anti-GD2 ch14.18/CHO antibody with Vgamma9Vdelta2+gammadelta T cells.Oncoimmunology.2016,5(1):e1025194.

[84]Daley D,Zambirinis CP,Seifert L,et al.gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation.Cell.Sep 8 2016,166(6):1485-1499 e1415.

[85]Huang Y,Heiser RA,Detanico TO,et al.gammadelta T cells affect IL-4 production and B-cell tolerance.Proc Natl Acad Sci U S A.Jan 6 2015,112(1):E39-48.

[86]Huang Y,Getahun A,Heiser RA,et al.gammadelta T Cells Shape Preimmune Peripheral B Cell Populations.J Immunol.Jan 1 2016,196(1):217-231.

[87]Mathews JA,Kasahara DI,Ribeiro L,et al.gammadelta T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice.PLoS One.2015,10(7):e0131236.

[88]Huang Y,Yang Z,Huang C,et al.gammadelta T Cell-Dependent Regulatory T Cells Prevent the Development of Autoimmune Keratitis.J Immunol.Dec 15 2015,195(12):5572-5581.

[89]Rani M,Zhang Q,Schwacha MG.Gamma delta T cells regulate wound myeloid cell activity after burn.Shock.Aug 2014,42(2):133-141.

[90]Rani M,Zhang Q,Oppeltz RF,et al.Gamma delta T cells regulate inflammatory cell infiltration of the lung after trauma-hemorrhage.Shock.Jun 2015,43(6):589-597.

[91]Long KM,Ferris MT,Whitmore AC,et al.gammadelta T Cells Play a Protective Role in Chikungunya Virus-Induced Disease.J Virol.Jan 2016,90(1):433-443.

[92]Soriano-Sarabia N,Archin NM,Bateson R,et al.Peripheral Vgamma9Vdelta2 T Cells Are a Novel Reservoir of Latent HIV Infection.PLoS Pathog.Oct 2015,11(10):e1005201.

[93]Daguzan C,Moulin M,Kulyk-Barbier H,et al.Aminobisphosphonates Synergize with Human Cytomegalovirus To Activate the Antiviral Activity of Vgamma9Vdelta2 Cells.J Immunol.Mar 1 2016,196(5):2219-2229.

[94]Kaminski H,Garrigue I,Couzi L,et al.Surveillance of gammadelta T Cells Predicts Cytomegalovirus Infection Resolution in Kidney Transplants.J Am Soc Nephrol.Feb 2016,27(2):637-645.

[95]Sell S,Dietz M,Schneider A,et al.Control of murine cytomegalovirus infection by gammadelta T cells.PLoS Pathog.Feb 2015,11(2):e1004481.

[96]Khairallah C,Netzer S,Villacreces A,et al.gammadelta T cells confer protection against murine cytomegalovirus(MCMV).PLoS Pathog.Mar 2015,11(3):e1004702.

[97]Blink SE,Caldis MW,Goings GE,et al.gammadelta T cell subsets play opposing roles in regulating experimental autoimmune encephalomyelitis.Cell Immunol.Jul 2014,290(1):39-51.

[98]Perko R,Kang G,Sunkara A,et al.Gamma delta T cell reconstitution is associated with fewer infections and improved eventfree survival after hematopoietic stem cell transplantation for pediatric leukemia.Biol Blood Marrow Transplant.Jan 2015,21(1):130-136.

[99]Dimova T,Brouwer M,Gosselin F,et al.Effector Vgamma9Vdelta2 T cells dominate the human fetal gammadelta T-cell repertoire.Proc Natl Acad Sci U S A.Feb 10 2015,112(6):E556-565.

[100]Jagannathan P,Kim CC,Greenhouse B,et al.Loss and dysfunction of Vdelta2+gammadelta T cells are associated with clinical tolerance to malaria.Sci Transl Med.Aug 27 2014,6(251):251ra117.

[101]Farrington LA,Jagannathan P,McIntyre TI,et al.Frequent Malaria Drives Progressive Vdelta2 T-Cell Loss,Dysfunction,and CD16 Up-regulation During Early Childhood.J Infect Dis.May 1 2016,213(9):1483-1490.

[102]Tan CT,Wistuba-Hamprecht K,Xu W,et al.Vdelta2+and alpha/ss T cells show divergent trajectories during human aging.Oncotarget.Jun 15 2016.

[103]McGill JL,Sacco RE,Baldwin CL,et al.Specific recognition of mycobacterial protein and peptide antigens by gammadelta T cell subsets following infection with virulent Mycobacterium bovis.J Immunol.Mar 15 2014,192(6):2756-2769.

[104]Peckham RK,Brill R,Foster DS,et al.Two distinct populations of bovine IL-17+T-cells can be induced and WC1+IL-17+gammadelta T-cells are effective killers of protozoan parasites.Sci Rep.2014,4:5431.

[105]Guzman E,Hope J,Taylor G,et al.Bovinegammadelta T cells are a major regulatory T cell subset.J Immunol.Jul 1 2014,193(1):208-222.

[106]Hsu H,Baldwin CL,Telfer JC.The endocytosis and signaling of thegammadelta T cell coreceptor WC1 are regulated by a dileucine motif.J Immunol.Mar 1 2015,194(5):2399-2406.