［1］Zhu Z，Zhu S，Guo X，Wang J，Wang D，Yan D，Tan X，Tang L，Zhu H，Yang Z，Jiang X，Ji Y，Zhang Y，Xu W. Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008. Virol J. 2010；7：300.

［2］Robinson CR，Doane FW，Rhodes AJ. Report of an outbreak of febrile illness with pharyngeal lesions and exanthem：Toronto，summer 1957；isolation of group A Coxsackie virus. Can Med Assoc J. 1958；79（8）：615-621.

［3］ALSOP J，FLEWETT TH，FOSTER JR.“Hand-foot-and-mouth disease”in Birmingham in 1959. Br Med J. 1960；2（5214）：1708-1711.

［4］Schmidt NJ，Lennette EH，Ho HH. An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis. 1974；129（3）：304-309.

［5］Ji H，Li L，Liu Y，Ge H，Wang X，Hu J，Wu B，Fu J，Zhang Z，Chen X，Zhang M，Ding Q，Xu W，Tang F，Zhou M，Wang H，Zhu F. Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province，China. Virol J. 2012；9：248.

［6］Melnick JL. Enterovirus type 71 infections：a varied clinical pattern sometimes mimicking paralytic poliomyelitis. Rev Infect Dis. 1984；6 Suppl 2：S387-390.

［7］Nagy G，Takátsy S，Kukán E，Mihály I，Dömök I. Virological diagnosis of enterovirus type 71 infections：experiences gained during an epidemic of acute CNS diseases in Hungary in 1978. Arch Virol. 1982；71（3）：217-227.

［8］Chumakov M，Voroshilova M，Shindarov L，Lavrova I，Gracheva L，Koroleva G，Vasilenko S，Brodvarova I，Nikolova M，Gyurova S，Gacheva M，Mitov G，Ninov N，Tsylka E，Robinson I，Frolova M，Bashkirtsev V，Martiyanova L，Rodin V. Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria. Arch Virol. 1979；60（3-4）：329-340.

［9］蔡丽君.手足口病的流行趋势.儿科药学杂志. 2008；14（3）：64.

［10］Lum LC，Wong KT，Lam SK，Chua KB，Goh AY. Neurogenic pulmonary oedema and enterovirus 71 encephalomyelitis. Lancet. 1998；352（9137）：1391.

［11］Chan LG，Parashar UD，Lye MS，Ong FG，Zaki SR，Alexander JP，Ho KK，Han LL，Pallansch MA，Suleiman AB，Jegathesan M，Anderson LJ. Deaths of children during an outbreak of hand，foot，and mouth disease in sarawak，malaysia：clinical and pathological characteristics of the disease. Clin Infect Dis. 2000；31（3）：678-683.

［12］Craig ME，Vale T，Robertson P，Rawlinson WD，Gould B. Enterovirus 71 infection in Australian expatriate children following an outbreak in Malaysia. J Paediatr Child Health. 1999；35（1）：107-108.

［13］WPRO Hand，Foot and Mouth Disease Situation Update 2011—24 July 2012. Western Pacific Regional Office of the World Health Organizaiton，2012.

［14］WHO Global Alert and Response（GAR）Undiagnosed illness in Cambodia-update 9 July 2012. World Health Organization，2012.

［15］Lee MK，Chan PK，Ho II，Lai WM. Enterovirus infection among patients admitted to hospital in Hong Kong in 2010：epidemiology，clinical characteristics，and importance of molecular diagnosis. J Med Virol. 2013；85 （10）：1811-1817.

［16］Puenpa J，Chieochansin T，Linsuwanon P，Korkong S，Thongkomplew S，Vichaiwattana P，Theamboonlers A，Poovorawan Y. Hand，foot，and mouth disease caused by coxsackievirus A6，Thailand，2012. Emerg Infect Dis. 2013；19（4）：641-643.

［17］Ooi MH，Wong SC，Lewthwaite P，Cardosa MJ，Solomon T. Clinical features，diagnosis，and management of enterovirus 71. Lancet Neurol. 2010；9（11）：1097-1105.

［18］Solomon T，Lewthwaite P，Perera D，Cardosa MJ，McMinn P，Ooi MH. Virology，epidemiology，pathogenesis，and control of enterovirus 71. Lancet Infect Dis. 2010；10（11）：778-790.

［19］Chang LY，Huang LM，Gau SS，Wu YY，Hsia SH，Fan TY，Lin KL，Huang YC，Lu CY，Lin TY. Neurodevelopment and cognition in children after enterovirus 71 infection. N Engl J Med. 2007；356 （12）：1226-1234.

［20］薛凤举.中国疾病预防与控制指南.北京：华夏出版社，2000.

［21］Ishimaru Y，Nakano S，Yamaoka K，Takami S. Outbreaks of hand，foot，and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system. Arch Dis Child. 1980；55（8）：583-588.

［22］Yamazaki K，Okuno Y. Genetic diagnosis and molecular epidemiological analyses of hand，foot and mouth disease which prevailed in Osaka Prefecture in 2000. Kansenshogaku Zasshi. 2001；75（11）：909-915.

［23］Shinohara M，Uchida K，Shimada S，Segawa Y，Hoshino Y. Characterization of enterovirus type 71 isolated in Saitama Prefecture in 2000. Kansenshogaku Zasshi. 2001；75（6）：490-494.

［24］Liu N，Xie J，Qiu X，Jia L，Wu Z，Ma Y，Wang Z，Li P，Ren X，Hao R，Wang L，Wang Y，Qiu S，Song H. An atypical winter outbreak of hand，foot，and mouth disease associated with human enterovirus 71，2010. BMC Infect Dis. 2014；14（1）：123.

［25］Yin YX，Ou ZY，Xu Y，Zhou R，Xia HM. Phylogenetic analysis of the VP1 gene of Enterovirus 71 in Guangzhou during the high occurrence period of 2008. Virus Genes. 2014；48（3）：538-542.

［26］Lu J，Zeng H，Zheng H，Yi L，Guo X，Liu L，Sun L，Tan X，Li H，Ke C，Lin J. Hand，foot and mouth disease in Guangdong，China，in 2013：new trends in the continuing epidemic. Clin Microbiol Infect. 2014；20（7）：O442-445.

［27］Tian H，Zhang Y，Sun Q，Zhu S，Li X，Pan Z，Xu W，Xu B. Prevalence of multiple enteroviruses associated with hand，foot，and mouth disease in Shijiazhuang City，Hebei province，China：outbreaks of coxsackieviruses a10 and b3. PLoS One. 2014；9（1）：e84233.

［28］Zheng S，Cao CX，Cheng JQ，Wu YS，Xie X，Xu M. Epidemiological features of hand-foot-and-mouth disease in Shenzhen，China from 2008 to 2010. Epidemiol Infect. 2013：1-12.

［29］于长水.天津市由CoxA16肠道病毒引起的手足口病流行.中华流行病学杂志. 1985；6（2）：66-69.

［30］刘晶星.现代医学微生物学［M］.北京：人民卫生出版社. 1999；1227-1242.

［31］Zheng ZM，He PJ，Caueffield D，Neumann M，Specter S，Baker CC，Bankowski MJ. Enterovirus 71 isolated from China is serologically similar to the prototype E71 BrCr strain but differs in the 5＇-noncoding region. J Med Virol. 1995；47（2）：161-167.

［32］张红，黄一伟.湖南省197例手足口病临床诊断病例的病原学检测结果.实用预防医学. 2008；15 （12）：1933-1935.

［33］杨洪，何雅青，周丽，等.深圳市2004年肠道病毒71型和柯萨奇病毒A16型的监测.疾病控制杂志. 2006；10（4）：389-391.

［34］Ng DK，Law AK，Cherk SW，Mak KL. First fatal case of enterovirus 71 infection in Hong Kong. Hong Kong Med J. 2001；7（2）：193-196.

［35］Komatsu H，Shimizu Y，Takeuchi Y，Ishiko H，Takada H. Outbreak of severe neurologic involvement associated with Enterovirus 71 infection. Pediatr Neurol. 1999；20（1）：17-23.

［36］Ho M，Chen ER，Hsu KH，Twu SJ，Chen KT，Tsai SF，Wang JR，Shih SR. An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med. 1999；341（13）：929-935.

［37］Chang LY，Lin TY，Huang YC，Tsao KC，Shih SR，Kuo ML，Ning HC，Chung PW，Kang CM. Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic，1998. Pediatr Infect Dis J. 1999；18（12）：1092-1096.

［38］Fujimoto T，Chikahira M，Yoshida S，Ebira H，Hasegawa A，Totsuka A，Nishio O. Outbreak of central nervous system disease associated with hand，foot，and mouth disease in Japan during the summer of 2000：detection and molecular epidemiology of enterovirus 71. Microbiol Immunol. 2002；46（9）：621-627.

［39］何家鑫，沈晓娜.手足口病流行特点及其防治.海峡预防医学杂志. 2001；7（3）：22-24.

［40］张爱香，李燕婷，张家琪，等.一起由肠道病毒71型引起手足口病暴发的调查.上海预防医学杂志. 2001；12：587-588.

［41］李桂刚，孙成阳，李维明.山东省招远市手足口病流行病学调查.预防医学文献信息. 2001；7（3）：259-261.

［42］王晓华，李文琳.小儿手足口病1602例报告.中华流行病学杂志. 2001；4（22）：272.

［43］杨智宏，朱启镕，李秀珠，等. 2002年上海儿童手足口病病例中肠道病毒71型和柯萨奇病毒A组16型的调查.中华儿科杂志. 2005；43（9）：648.

［44］吴艳. 1359例手足口病流行病学分析［J］.中国热带医学. 2006；6（4）：607.

［45］薛家芹，杨会利，陈勇，等. 2003年泰安市部分手足口病住院病例分析.预防医学论坛. 2005；11（6）：676-677.

［46］李燕婷.手足口病的流行病学特征及预防控制.上海预防医学杂志. 2008；20（6）：316-317.

［47］朱理业，丁振涛，万俊峰，等.阜阳市手足口病（EV71感染）重症病例流行病学调查分析.安徽医学. 2008；29（5）：595-596.

［48］Ooi EE，Phoon MC，Ishak B，Chan SH. Seroepidemiology of human enterovirus 71，Singapore. Emerg Infect Dis. 2002；8（9）：995-997.

［49］Herrero LJ，Lee CS，Hurrelbrink RJ，Chua BH，Chua KB，McMinn PC. Molecular epidemiology of enterovirus 71 in peninsular Malaysia，1997-2000. Arch Virol. 2003；148（7）：1369-1385.

［50］周世力，李琳琳，何雅青.深圳市肠道病毒71型血清流行病学初步调查.热带医学杂志. 2007；7 （1）：66-67.

［51］Chang LY，Tsao KC，Hsia SH，Shih SR，Huang CG，Chan WK，Hsu KH，Fang TY，Huang YC，Lin TY. Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan. JAMA. 2004；291（2）：222-227.

［52］Ma E，Lam T，Chan KC，Wong C，Chuang SK. Changing epidemiology of hand，foot，and mouth disease in Hong Kong，2001-2009. Jpn J Infect Dis. 2010；63（6）：422-426.

［53］Singh S，Poh CL，Chow VT. Complete sequence analyses of enterovirus 71 strains from fatal and non-fatal cases of the hand，foot and mouth disease outbreak in Singapore（2000）. Microbiol Immunol. 2002；46（11）：801-808.

［54］Lee MS，Chang LY. Development of enterovirus 71 vaccines. Expert Rev Vaccines. 2010；9（2）：149-156.

［55］Yang KD，Yang MY，Li CC，Lin SF，Chong MC，Wang CL，Chen RF，Lin TY. Altered cellular but not humoral reactions in children with complicated enterovirus 71 infections in Taiwan. J Infect Dis. 2001；183（6）：850-856.

［56］Chang LY，Chang IS，Chen WJ，Huang YC，Chen GW，Shih SR，Juang JL，Shih HM，Hsiung CA，Lin TY，Huang LM. HLA-A33 is associated with susceptibility to enterovirus 71 infection. Pediatrics. 2008；122（6）：1271-1276.

［57］别芹芹，邱冬生，胡辉，鞠斌.我国手足口病时空分布特征的GIS分析.地球信息科学学报. 2010；12 （3）：380-384.

［58］Solomon T，Lewthwaite P，Perera D，Cardosa MJ，McMinn P，Ooi MH. Virology，epidemiology，pathogenesis，and control of enterovirus 71. Lancet Infect Dis. 2010；10（11）：778-790.

［59］Ang LW，Koh BK，Chan KP，Chua LT，James L，Goh KT. Epidemiology and control of hand，foot and mouth disease in Singapore，2001-2007. Ann Acad Med Singapore. 2009；38（2）：106-112.

［60］Chen SC，Chang HL，Yan TR，Cheng YT，Chen KT. An eight-year study of epidemiologic features of enterovirus 71 infection in Taiwan. Am J Trop Med Hyg. 2007；77（1）：188-191.

［61］Urashima M，Shindo N，Okabe N. Seasonal models of herpangina and hand-foot-mouth disease to simulate annual fluctuations in urban warming inTokyo. Jpn J Infect Dis. 2003；56（2）：48-53.

［62］Zou XN，Zhang XZ，Wang B，Qiu YT. Etiologic and epidemiologic analysis of hand，foot，and mouth disease in Guangzhou city：a review of 4，753 cases. Braz J Infect Dis. 2012；16（5）：457-465.

［63］Yin XG，Yi HX，Shu J，Wang XJ，Wu XJ，Yu LH. Clinical and epidemiological characteristics of adult hand，foot，and mouth disease in northern Zhejiang，China，May 2008-November 2013. BMC Infect Dis. 2014；14：251.

［64］Kaminska K，Martinetti G，Lucchini R，Kaya G，Mainetti C. Coxsackievirus A6 and Hand，Foot and Mouth Disease：Three Case Reports of Familial Child-to-Immunocompetent Adult Transmission and a Literature Review. Case Rep Dermatol. 2013；5（2）：203-209.

［65］周勇，庞志明，陈艳芳，虞华珍，李小向.广州白云区儿童多次罹患手足口病的流行病学特征.微生物学免疫学进展. 2012；40（2）：36-39.

［66］郭汝宁，张正敏，杨芬，等.广东省手足口病流行特征和危险因素研究.中华流行病学杂志. 2009；30 （5）：530.

［67］徐文体，高璐，张颖，等.天津市手足口病患儿危险因索的病例对照研究.中华流行病学杂志. 2009；30（1）：100.

［68］Li W，Teng G，Tong H，Jiao Y，Zhang T，Chen H，Wu H. Study on risk factors for severe hand，foot and mouth disease in China. PLoS One. 2014；9（1）：e87603.

［69］Kim SJ，Kim JH，Kang JH，Kim DS，Kim KH，Kim KH，Kim YH，Chung JY，Bin JH，Jung da E，Kim JH，Kim HM，Cheon DS，Kang BH，Seo SY. Risk factors for neurologic complications of hand，foot and mouth disease in the Republic of Korea，2009. J Korean Med Sci. 2013；28（1）：120-127.

［70］Ooi MH，Wong SC，Mohan A，Podin Y，Perera D，Clear D，del Sel S，Chieng CH，Tio PH，Cardosa MJ，Solomon T. Identification and validation of clinical predictors for the risk of neurological involvement in children with hand，foot，and mouth disease in Sarawak. BMC Infect Dis. 2009；9（3）：1-12.