参考文献
[1] 张瑞,王林,耿智敏.下一代基因测序技术在胆囊癌基因组研究中的应用进展[J].中华肝脏外科手术学电子杂志,2018,7(4):341-344.
[2] JAVLE M,BEKAII-SAAB T,JAIN A,et al.Biliary cancer:Utility of next-generation sequencing for clinical management[J].Cancer.2016,122(24):3838-3847.
[3] JAVLE M,RASHID A,CHURI C,et al.Molecular characterization of gallbladder cancer using somatic mutation profiling[J].Hum pathol,2014,45(4):701-708.
[4] LI M,ZHANG Z,LI X,et al.Whole-exsome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway[J].Nat Genet,2014,46(8):872-876.
[5] 卜范峰,王燕.基因芯片技术在肿瘤相关基因筛选及肿瘤治疗中的应用[J].医学分子生物学杂志,2015(1):59-62.
[6] SEKINE S,SHIMADA Y,NAGATA T,et al.Role of aquaporin-5 in gallbladder carcinoma[J].Eur Surg Res,2013,51(3-4):108-117.
[7] PERKINS G,LU H,GARLAN F,et al.Droplet-Based Digital PCR:Application in Cancer Research[J].Adv Clin Chem,2017,79:43-91.
[8] LU X,ZHOU C,LI R F,et al.Kindlin-2 promotes gallbladder cancer metastasis and invasion by inducing epithelialmesenchymal transition[J].Zhonghua Wai Ke Za Zhi,2018,56(8):617-622.
[9] KAWAMOTO T,SHODA J,MIYAHARA N,et al.Expression of MUC1 recognized by a monoclonal antibody MY.1E12 is a useful biomarker for tumor aggressiveness of carcinoma of the gallbladder[J].Clin Exp Metastasis,2004,21(4):353-362.
[10] IKEDA T,NAKAYAMA Y,HAMADA Y,et al.FU-MK-1 expression in human gallbladder carcinoma:an antigenic prediction marker for a better postsurgical prognosis[J].Am J clin Pathol,2009,132(1):111-117.
[11] 邹声泉,张林 .全国胆囊癌临床流行病学调查报告[J].中国实用外科杂志,2000(1):43-46.
[12] AGARWAL A,PAREEK P,MISRA S.Carcinoma Gallbladder——an Indian Problem[J].Indian J Surg,2016,7(1):2-3.
[13] 康慧媛,汪洋,金淑媛,等.骨髓形态联合血清肿瘤标志物检测对淋巴瘤的诊断及预后意义[J].中国实验血液学杂志,2015,23(2):416-419.
[14] 崔大鹏,张迎春 .CA19-9、CEA、CA242 联合检测对胆管癌诊断的评估价值[J].解放军医药杂志,2017,29(2):103-106.
[15] WANG Y F,FENG F L,ZHAO X H,et al.Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer[J].World J Gastroenterol,2014,20(14):4085-4092.
[16] 张鹏,魏瑛,黄鹿,等 .CA19-9、CA125 和碱性磷酸酶对胆囊癌临床分期的意义[J].胃肠病学,2012,17(1):33-35.
[17] DUFFY M J,HARBECK N,NAP M,et al.Clinical use of biomarkers in breast cancer:Updated guidelines from the European Group on Tumor Markers[J].Eur J Cancer,2017,75:284-298.
[18] 何丽琳,沈永祥.四项肿瘤标志物联合测定对胆囊癌患者预后的影响[J].检验医学与临床,2018,15(7):1014-1017.
[19] SICKLICK J K,FANTA P T,SHIMABUKURO K,et al.Genomics of gallbladder cancer:the case for biomarker-driven clinical trial design[J].Cancer Metastasis Rev,2016,35(2):263-275.
[20] VIDAURRE T,CASAVILCA S,MONTENEGRO P,et al.Tumor Protein p53 and K-ras Gene Mutations in Peruvian Patients with Gallbladder Cancer[J].Asian Pac J Cancer Prev,2019,20(1):289-294.
[21] DOBRZYCKA B,TERLIKOWSKI S J,MAZUREK A,et al.Circulating free DNA,p53 antibody and mutations of KRAS gene in endometrial cancer[J].Int J Cancer,2010,127(3):612-621.
[22] 卢晖,夏建兵,翁黎明,等 .c-Myc、k-Ras、p16 在胆囊癌细胞中的表达及临床意义[J].上海医药,2014,35(18):27-29.
[23] 姚建国,王春华,刘颖 .胆囊腺癌 Her2 阳性表达的临床意义[J].中华病理学杂志,2017,46(4):245-248.
[24] LI M,ZHANG Z,LI X,et al.Whole-exosome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway[J].Nat Genet,2014,46(8):872-876.
[25] 刘会春,鲁贻民,谈燚.雌激素受体、孕激素受体、c-erbB2、p53和细胞增殖核抗原在胆囊癌中的表达及意义[J].中华实验外科杂志,2005(12):1532.
[26] CHOI H J,YUN S S,KIM H J,et al.Expression of p16 protein in gallbladder carcinoma and its precancerous conditions[J].Hepatogastroenterology,2010,57(97):18-21.
[27] JOSEPH C G,DARRAH E,SHAH A A,et al.Association of the autoimmune disease scleroderma with an immunologic response to cancer[J].Science,2014,343(6167):152-157.
[28] GOLDIN R D,ROA J C.Gallbladder cancer:a morphological and molecular update[J].Histopathology,2009,55(2):218-229.
[29] CRISTOFANILLI M,BUDD G T,ELLIS M J,et al.Circulating tumor cells,disease progression,and survival in metastatic breast cancer[J].N Engl J Med,2004,351(8):781-791.
[30] BATTH I S,MITRA A,MANIER S,et al.Circulating tumor markers:harmonizing the yin and yang of CTCs and ctDNA for precision medicine[J].Ann Oncol,2017,28(3):468-477.
[31] AWASTHI N P,KUMARI S,NEYAZ A,et al.EpCAM-based flow cytometric detection of circulating tumor cells in gallbladder carcinoma cases[J].Asian Pac J Cancer Prev,2017,18(12):3429-3437.
[32] BUTLER T M,SPELLMAN P T,GRAY J.Circulating-tumor DNA as an early detection and diagnostic tool[J].Curr Opin Genet Dev,2017,42:14-21.
[33] KUMARI S,TEWARI S,HUSAIN N,et al.Quantification of Circulating Free DNA as a Diagnostic Marker in Gall Bladder Cancer[J].Pathol Oncol Res,2017,23(1):91-97.
[34] KINUGASA H,NOUSO K,AKO S,et al.Liquid biopsy of bile for the molecular diagnosis of gallbladder cancer[J].Cancer Biol Ther,2018,19(10):934-938.
[35] CHEN F,WANG N,TAN H Y,et al.The functional roles of exosomes-derived long non-coding RNA in human cancer[J].Cancer Biol Ther,2019,20(5):583-592.
[36] SEVERINO V,DUMONCEAU J M,DELHAYE M,et al.Extracellular vesicles in bile as markers of malignant biliary stenoses[J].Gastroenterology,2017,153(2):495-504,e8.